Author

T. Sakaguchi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 3 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

T. Irie· 2 shared A. Higashiura· 1 shared A. Ito· 1 shared A. Saito· 1 shared A. Takaori-Kondo· 1 shared A. Yamamoto· 1 shared D. Oikawa· 1 shared E. P. Butlertanaka· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersImmunology

T. Irie

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

LRRK2 G2019S promotes the development of colon cancer via modulating intestinal inflammation

Z. Kang, Y. Wang, J. Z. Gao, T. Sakaguchi, T. Maretzky, P. Gurung, S. Short, Y. Xiong

This study shows that LRRK2 G2019S promotes colon cancer by enhancing intestinal inflammation and tumor growth in mice.

bioRxiv · Jun 28, 2023Immunology

Optineurin deficiency impairs autophagy to cause interferon beta overproduction and increased survival of mice following viral infection

M. Fukushi, R. Ohsawa, Y. Okinaka, D. Oikawa, T. Kiyono, M. Moriwaki, T. Irie, K. Oda, Y. Kamei, F. Tokunaga, Y. Sotomaru, H. Maruyama, H. Kawakami, T. Sakaguchi

This study shows that optineurin deficiency leads to IFNβ overproduction and increased survival in mice during viral infection due to impaired autophagy.

bioRxiv · Mar 13, 2023 · PreprintImmunology

Germinal center-derived broadly neutralizing antibodies adapt to SARS-CoV-2 antigenic drift

K. Shitaoka, Y. Kawano, A. Higashiura, Y. Mizoguchi, T. Hashiguchi, N. Nishimichi, S. Huang, A. Ito, A. Yamamoto, S. Ohki, M. Kanda, T. Taniguchi, Y. Yokosaki, S. Okada, T. Sakaguchi, T. Yasuda

The paper identifies neutralizing antibodies from early SARS-CoV-2 infections that retain activity against Omicron and other variants, highlighting the role of germinal center mutations in their broad neutralization.

bioRxiv · Jan 26, 2022 · PreprintImmunology

SARS-CoV-2 spike P681R mutation, a hallmark of the Delta variant, enhances viral fusogenicity and pathogenicity

A. Saito, T. Irie, R. Suzuki, T. Maemura, H. Nasser, K. Uriu, Y. Kosugi, K. Shirakawa, K. Sadamasu, I. Kimura, J. Ito, J. Wu, K. Iwatsuki-Horimoto, M. Ito, S. Yamayoshi, , K. Sato

This study shows the P681R mutation in the SARS-CoV-2 spike protein enhances fusogenicity and pathogenicity in the Delta variant compared to the prototypic virus.

bioRxiv · Jun 17, 2021Microbiology