Microbial Invasion and Immunosuppression Drives Adenoma Progression in Early Colorectal Cancer Development
Wei Liang, Lisa Falk, Daniele Lucarelli, Philipp Putze, Amira Metwaly, Yiran Zheng, Fabian Springer, Thomas Winogrodzki, Qixia Chan, Theresa M. Pauli, Yue Zhang, Georg Zeller, Matthias Meier, Angelika Schnieke, Friederike Ebner, , Krzysztof Flisikowski
The paper shows bacterial invasion and neutrophil immunosuppression drive adenoma progression in a porcine FAP model using single-cell RNA sequencing and spatial transcriptomics.
bioRxiv · Oct 12, 2026 · PreprintCancer Biology