The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects
Erwan Lambert, Orthis Saha, Bruna Soares Landeira, Ana Raquel Melo de Farias, Xavier Hermant, Arnaud Carrier, Alexandre Pelletier, Johanna Gadaut, Lindsay Davoine, Cloé Dupont, Philippe Amouyel, Amélie Bonnefond, Frank Lafont, Farida Abdelfettah, Patrik Verstreken, , Pierre Dourlen
This study shows that BIN1 isoform1 causes early endosome defects and neurodegeneration in Drosophila and human neurons, linking it to Alzheimer's disease pathology.
Acta Neuropathologica Communications · Jan 8, 2022Peer-reviewedNeuroscience