The Alzheimer's disease risk gene BIN1 modulates neural network activity via the regulation of L-type calcium channel expression in human-induced neurons
Orthis Saha, Ana Raquel Melo de Farias, Alexandre Pelletier, Dolores Siedlecki‐Wullich, Johanna Gadaut, Bruna Soares Landeira, Arnaud Carrier, Anaïs-Camille Vreulx, Karine Guyot, Amélie Bonnefond, Philippe Amouyel, Claudio Marcos Queiroz, Devrim Kilinc, Fabien Delahaye, Jean‐Charles Lambert, Marcos R. Costa
This study shows BIN1 regulates L-type calcium channels in neurons, affecting calcium homeostasis and electrical activity, and links these changes to Alzheimer's disease pathology.
bioRxiv · Jan 18, 2022 · PreprintNeuroscience