TGFβ superfamily signaling regulates the state of human stem cell pluripotency and competency to create telencephalic organoids
Momoko Watanabe, Jillian R. Haney, Neda Vishlaghi, Felix Turcios, Jessie E. Buth, Wen Gu, Amanda J. Collier, Osvaldo A. Miranda, Di Chen, Shan Sabri, Amander T. Clark, Kathrin Plath, Heather R. Christofk, Michael J. Gandal, Bennett G. Novitch
This study shows that maintaining human pluripotent stem cells with feeders improves cortical organoid formation by activating TGFβ signaling and naive pluripotency genes, which can be mimicked with TGFβ growth factors.
bioRxiv · Dec 13, 2019 · PreprintDevelopmental Biology