Momoko Watanabe

Spatial engineering of posterior signaling centers in cerebral organoids via controlled morphogen exposure within hydrogels

This paper introduces a hydrogel platform to spatially engineer posterior signaling centers in cerebral organoids through controlled morphogen exposure, improving spatial organization and cellular diversity.

Morphogen-guided neocortical organoids recapitulate regional areal identity and model neurodevelopmental disorder pathology

This study develops a method to generate neocortical organoids with distinct anterior-posterior molecular signatures and uses them to model Fragile X Syndrome pathology.

Identification of neural oscillations and epileptiform changes in human brain organoids

This study identifies neural oscillations and epileptiform changes in human brain organoids derived from MECP2 mutant patients using calcium imaging and extracellular recordings.

TGFβ superfamily signaling regulates the state of human stem cell pluripotency and competency to create telencephalic organoids

This study shows that maintaining human pluripotent stem cells with feeders improves cortical organoid formation by activating TGFβ signaling and naive pluripotency genes, which can be mimicked with TGFβ growth factors.