Shan Sabri

CellCage™ Technology Enables High-throughput Isolation of Defined Cell Combinations to Resolve the Determinants of CAR-T mediated Cytotoxicity

The paper introduces CellCage™ technology to isolate defined cell combinations for high-throughput analysis of CAR-T cell cytotoxicity, revealing functional heterogeneity and cooperative behavior in T cell-mediated killing.

Scalable longitudinal imaging and transcriptomics of cells in dynamic enclosures

This paper develops a platform for longitudinal imaging and transcriptomics of live cells, revealing adaptive drug-resistant states and key drivers of cellular function through integrated analysis.

Linking live-cell behavior to transcriptional responses across perturbations using dynamic caging

This study uses dynamic caging to link live-cell behavior with transcriptional responses across perturbations, revealing new insights into immune and inflammatory gene regulation.

An Xist-dependent protein assembly mediates Xist localization and gene silencing

The paper shows that Xist RNA forms a protein condensate with binding proteins to establish the Xi-compartment and maintain gene silencing.

TGFβ superfamily signaling regulates the state of human stem cell pluripotency and competency to create telencephalic organoids

This study shows that maintaining human pluripotent stem cells with feeders improves cortical organoid formation by activating TGFβ signaling and naive pluripotency genes, which can be mimicked with TGFβ growth factors.

A single cell transcriptomic analysis of human neocortical development

The paper defines single cell transcriptomic profiles of 40,000 human neocortical cells to identify cell types, developmental trajectories, and disease-related gene expression.