Mitochondrial stress signaling shapes the nuclear response to loss of the chromatin reader MRG-1
Carole Zaratiegui, Fernanda Rezende Pabst, Maria-Jesus Rodriguez Palero, Peter Meister, Marta Artal‐Sanz, Daphne S. Cabianca
The paper shows that loss of MRG-1 activates a mitochondrial stress response, which contributes to nuclear changes and adaptation to mitochondrial stress rather than just heterochromatin organization.
bioRxiv · Aug 19, 2026 · PreprintCell Biology