Daphne S. Cabianca

This study shows HLH-30/TFEB is essential for chromatin reorganization and cell quiescence during starvation in C. elegans, with loss of HLH-30 disrupting cell cycle arrest and causing premature developmental activation.

The paper shows that loss of MRG-1 activates a mitochondrial stress response, which contributes to nuclear changes and adaptation to mitochondrial stress rather than just heterochromatin organization.

This study shows that MTRR-1 regulates heterochromatin through mitochondrial homeostasis, not methionine synthesis, in C. elegans.

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