Exploiting the Achilles' Heel of Viral RNA Processing to Develop Novel Antivirals
Ali Zahedi Amiri, Choudhary Ahmed, Subha Dahal, Filomena Grosso, Haomin Leng, Peter Stoilov, Maria Mangos, Johanne Toutant, Lulzim Shkreta, Liliana Attisano, Benoı̂t Chabot, Martha Brown, Mario Huesca, Alan Cochrane
This paper identifies 5342191 as a broad-spectrum antiviral that inhibits HIV-1, adenovirus, coronavirus, and influenza by altering viral RNA accumulation and structural protein expression.
Viruses · Dec 31, 2024Peer-reviewedMicrobiology