Dyslipidemic SPTLC3 Integrates Bile Acid-FXR Signaling with Sphingolipid Remodeling in MASLD
Michele Visentin, Zhibo Gai, Anna Kovilakath, Francesca De Luca, Grigorios Panteloglou, Alaa Othman, Mingxia Liu, Francesca Barone, Imme Garrelfs, Joanne Verheij, Belle Vivica van Rosmalen, Ting Gui, Bin Yan, Zhiyong Zhang, Andreas J. Hülsmeier, , Museer A. Lone
This study identifies SPTLC3's role in integrating bile acid-FXR signaling with sphingolipid remodeling in MASLD, showing its dysregulation in human liver and association with disease.
bioRxiv · Aug 25, 2025 · PreprintBiochemistry