Author

Essa M. Saied

Suez Canal UniversityORCID 0000-0002-7342-6200Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:comparative / phylogenetic analysis· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Christoph ArenziD· 3 shared Andreas J. HülsmeieriD· 2 shared Thorsten HornemanniD· 2 shared Adam Majcher· 1 shared Alaa OthmaniD· 1 shared Anna KovilakathiD· 1 shared Arnold von EckardsteiniD· 1 shared Belle Vivica van RosmaleniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersBiochemistry

Christoph ArenzORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Fine-tuned synthetic transcription factors for production of 3' phosphoadenosine-5'-phosphosulfate in yeast

Madhushruti Borah, Shanna Gu, Essa M. Saied, Christoph Arenz, Mattheos A. G. Koffas, Gita Naseri

This paper improves synthetic transcription factors in yeast to enhance production of 3'-phosphoadenosine-5'-phosphosulfate (PAPS) through engineered loop flexibility and stability.

Microbial Cell Factories · Jul 27, 2026Peer-reviewedSynthetic Biology

CYP4F2-mediated ω-hydroxylation of 1-deoxysphingolipids reveals a new hepatic detoxification pathway

Adam Majcher, Essa M. Saied, Zoltán Kutalik, Maftuna Shamshiddinova, Andreas J. Hülsmeier, Par Bjorklund, Elkhan Yusifov, Irina Alecu, Christoph Arenz, Thorsten Hornemann

This study identifies CYP4F2 as a key enzyme mediating ω-hydroxylation of 1-deoxySLs, revealing a new hepatic detoxification pathway that reduces their cytotoxicity.

bioRxiv · May 14, 2026 · PreprintBiochemistry

Dyslipidemic SPTLC3 Integrates Bile Acid-FXR Signaling with Sphingolipid Remodeling in MASLD

Michele Visentin, Zhibo Gai, Anna Kovilakath, Francesca De Luca, Grigorios Panteloglou, Alaa Othman, Mingxia Liu, Francesca Barone, Imme Garrelfs, Joanne Verheij, Belle Vivica van Rosmalen, Ting Gui, Bin Yan, Zhiyong Zhang, Andreas J. Hülsmeier, , Museer A. Lone

This study identifies SPTLC3's role in integrating bile acid-FXR signaling with sphingolipid remodeling in MASLD, showing its dysregulation in human liver and association with disease.

bioRxiv · Aug 25, 2025 · PreprintBiochemistry