Targeting neuronal homeostasis to prevent seizures
Fred Mulroe, Wei‐Hsiang Lin, Connie Mackenzie‐Gray Scott, Najat Aourz, Yuen Ngan Fan, Graham Coutts, R. Ryley Parrish, Ilse Julia Smolders, Andrew J. Trevelyan, Robert C. Wykes, Stuart McRae Allan, Sally Freeman, Richard Baines
This study identifies a novel anticonvulsant compound that targets neuronal homeostasis by increasing Pumilio expression, showing efficacy in Drosophila and mouse seizure models.
bioRxiv · Mar 7, 2022 · PreprintNeuroscience