Graham Coutts

Inflammatory responses following CRISPR modification of the nuclear localisation sequence in endogenous interleukin-1α

This study disrupts the nuclear localisation sequence of endogenous IL-1α in mice and examines its effects on inflammatory responses, finding no significant changes in LPS-induced transcriptional signatures or IL-1 release.

Targeting neuronal homeostasis to prevent seizures

This study identifies a novel anticonvulsant compound that targets neuronal homeostasis by increasing Pumilio expression, showing efficacy in Drosophila and mouse seizure models.

Selective Liposomal Transport Through Blood Brain Barrier Disruption in Ischaemic Stroke Reveals Two Distinct Therapeutic Opportunities

This study shows liposomes can selectively enter the brain after stroke through two distinct BBB disruption phases, offering new therapeutic opportunities for targeted drug delivery.