Proteostasis sustains T cell differentiation potential and tumor-infiltrating lymphocyte function
Nicole E. Scharping, Xuezhen Ge, Maria I. Matias, Fulin Jiang, Allison Cafferata, Maximilian Heeg, Alexander Monell, Giovanni Galletti, Kitty P. Cheung, Angelica E. Rock, Nick Thao, Sydnye L. Shuttleworth, Michael A. Bauer, Kennidy K. Takehara, Amir Ferry, , Ananda W. Goldrath
This study identifies proteostasis as critical for T cell differentiation potential and tumor-infiltrating lymphocyte function, showing that maintaining E3 ubiquitin ligases improves anti-tumor responses.
Cell · Nov 1, 2025Peer-reviewedImmunology