Maximilian Heeg

SpatialTRACE extends anatomical annotations from a few structures to tissue-wide maps using graph and image-based models in spatial transcriptomics and microscopy.

FITdb integrates and harmonizes functional genomics datasets from immune cell studies to enable cross-study comparisons and gene function analysis.

This study identifies proteostasis as critical for T cell differentiation potential and tumor-infiltrating lymphocyte function, showing that maintaining E3 ubiquitin ligases improves anti-tumor responses.

This study identifies two distinct CD4+ T cell populations in inflamed lungs, showing that TCF1+ progenitor cells in tertiary lymphoid structures drive Th2 responses in allergic disease.

The paper investigates how spatial location influences the functional diversity of memory CD8 T cells by analyzing their transcriptomes in the small intestine.