TEAD-targeting small molecules induce a cofactor switch to regulate the Hippo pathway
Alissa D. Guarnaccia, Thijs J. Hagenbeek, Wendy Lee, Noelyn M. Kljavin, Meena Choi, Benjamin J. Tombling, Carsten Peukert, Gözde Ulas, Vasumathi Kameswaran, Daniel Le, Sayantanee Paul, Samir Vaidya, Jason R. Zbieg, James J. Crawford, Bence Dániel, , Jennie Rebecca Lill
The paper identifies small molecules that induce a cofactor switch in TEAD proteins from YAP to VGLL4, repressing pro-growth gene networks and showing anti-proliferative effects.
Proceedings of the National Academy of Sciences · Jul 3, 2025Peer-reviewedCancer Biology