G. Cartron

The SUMOylation inhibitor TAK-981 (Subasumstat) triggers IFN-I-dependent activation of Natural Killer cells against Acute Myeloid Leukemias.

This paper shows that TAK-981 activates NK cells against AML by inducing IFN-I secretion, enhancing their cytotoxicity and cytokine production.

Arginine-dependent hypusination of the eukaryotic translation initiation factor (eIF)5A drives erythroid lineage differentiation

The paper shows that arginine metabolism via hypusination of eIF5A regulates erythroid differentiation and that impaired eIF5A activity leads to erythroid disorders.

Human Cytomegalovirus modifies placental small extracellular vesicle secretion and composition towards a proviral phenotype to enhance infection of fetal recipient cells

This study shows hCMV infection alters placental sEVs to promote viral spread to fetal cells.

Human cytomegalovirus infection changes the pattern of surface markers of small extracellular vesicles isolated from first trimester placental histocultures

This study examines how human cytomegalovirus infection alters surface markers on placental-derived small extracellular vesicles from first trimester histocultures.

Nonclassical monocytes are prone to migrate into tumor in diffuse large B-cell lymphoma

The paper assesses monocyte subsets in DLBCL patients, finding that nonclassical monocytes are decreased in peripheral blood and prone to migrate into tumors, correlating with adverse outcomes.

The NADPH oxidase NOX2 is a marker of adverse prognosis involved in chemoresistance of Acute Myeloid Leukemias

This study identifies NOX2 as a marker of poor prognosis and a contributor to chemoresistance in AML, showing its upregulation in drug-resistant cells and association with adverse outcomes.

Ubiquitin and SUMO conjugation as biomarkers of Acute Myeloid Leukemias response to chemotherapies

This paper identifies ubiquitin and SUMO conjugation biomarkers to predict AML response to chemotherapy and develops an assay to measure them.

Targeting the methyltransferase SETD8 impairs tumor cell survival and overcomes drug resistance independently of p53 status in multiple myeloma

This study shows that inhibiting SETD8 reduces multiple myeloma cell survival and overcomes drug resistance regardless of p53 status.

Targeting the SUMO pathway primes all-trans-retinoic acid-induced differentiation of non promyelocytic Acute Myeloid Leukemias

This study shows that inhibiting the SUMO pathway enhances the effectiveness of all-trans-retinoic acid in treating non-APL AMLs by promoting differentiation and reducing proliferation.