Author

G. Ciossani

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Assay:proteomics· 3 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Musacchio· 3 shared S. Wohlgemuth· 3 shared E. D'Amico· 2 shared S. Maffini· 2 shared V. Cmentowski· 2 shared A. Alex· 1 shared A. Castiglioni· 1 shared A. Davis· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersCell Biology

A. Musacchio

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

NF1 modulates microtubule repair and sensitivity to antibody-drug conjugates

B. Achutti Duso, E. Messuti, G. Tini, E. Bonetti, A. Castiglioni, G. Frige, G. Ciossani, S. Monzani, C. Soriani, D. Khuntsariya, N. Roda, A. Polazzi, M. R. Ippolito, E. Gavilan Dorronzoro, E. Mane, , L. Mazzarella

This study shows that NF1 loss increases sensitivity to the ADC T-DM1 by modulating microtubule repair and dynamics, identifying NF1 as a predictive biomarker for ADC response.

bioRxiv · Dec 6, 2023 · PreprintCancer Biology

A mechanism that integrates microtubule motors of opposite polarity at the kinetochore corona

V. Cmentowski, E. D'Amico, G. Ciossani, S. Wohlgemuth, M. Owa, B. D. Dynlacht, A. Musacchio

The paper identifies CENP-E's role in regulating DD kinetochore loading through the corona scaffold, ensuring coordinated bidirectional transport.

bioRxiv · Apr 25, 2023 · PreprintCell Biology

Structure of the RZZ complex and molecular basis of Spindly-driven corona assembly at human kinetochores

T. Raisch, G. Ciossani, E. d'Amico, V. Cmentowski, S. Carmignani, S. Maffini, F. Merino, S. Wohlgemuth, I. R. Vetter, S. Raunser, A. Musacchio

The paper reports the structure of the RZZ complex and demonstrates the molecular mechanism of corona assembly at human kinetochores using cryo-EM and in vitro assays.

bioRxiv · Dec 3, 2021Biochemistry

Electroporated recombinant proteins as tools for in vivo functional complementation, imaging, and chemical biology

A. Alex, V. Piano, S. Polley, M. Stuiver, S. Voss, G. Ciossani, K. Overlack, B. Voss, S. Wohlgemuth, A. Petrovic, Y.-W. Wu, P. Selenko, A. Musacchio, S. Maffini

This study demonstrates that electroporation can deliver recombinant proteins into human cells, maintaining their localization, function, and interactions, making it a versatile tool for chemical and synthetic biology.

bioRxiv · May 8, 2019Cell Biology