Author

S. Maffini

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. Musacchio· 3 shared S. Wohlgemuth· 3 shared E. d'Amico· 2 shared G. Ciossani· 2 shared I. R. Vetter· 2 shared P. Janning· 2 shared V. Cmentowski· 2 shared A. Alex· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersBiochemistry

A. Musacchio

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Targeting oncogenic KRasG13C with nucleotide-based covalent inhibitors

L. Goebel, T. Kirschner, S. Koska, A. Rai, P. Janning, S. Maffini, H. Vatheuer, P. Czodrowski, R. S. Goody, M. P. Mueller, D. Rauh

This study designs and evaluates nucleotide-based covalent inhibitors for KRasG13C, showing they block nucleotide exchange and oncogenic signaling.

bioRxiv · Jul 25, 2022Cancer Biology

Conformational transitions of the mitotic adaptor Spindly underlie its interaction with Dynein and Dynactin

E. d'Amico, M. Ud Din Ahmad, V. Cmentowski, M. Girbig, F. Mueller, S. Wohlgemuth, A. Brockmeyer, S. Maffini, P. Janning, I. R. Vetter, A. P. Carter, A. Perrakis, A. Musacchio

The paper shows Spindly adopts a closed conformation that blocks Dynein-Dynactin binding, and mutations induce an open state that enables interaction, with kinetochores promoting Spindly activation.

bioRxiv · Feb 2, 2022Biochemistry

Structure of the RZZ complex and molecular basis of Spindly-driven corona assembly at human kinetochores

T. Raisch, G. Ciossani, E. d'Amico, V. Cmentowski, S. Carmignani, S. Maffini, F. Merino, S. Wohlgemuth, I. R. Vetter, S. Raunser, A. Musacchio

The paper reports the structure of the RZZ complex and demonstrates the molecular mechanism of corona assembly at human kinetochores using cryo-EM and in vitro assays.

bioRxiv · Dec 3, 2021Biochemistry

Electroporated recombinant proteins as tools for in vivo functional complementation, imaging, and chemical biology

A. Alex, V. Piano, S. Polley, M. Stuiver, S. Voss, G. Ciossani, K. Overlack, B. Voss, S. Wohlgemuth, A. Petrovic, Y.-W. Wu, P. Selenko, A. Musacchio, S. Maffini

This study demonstrates that electroporation can deliver recombinant proteins into human cells, maintaining their localization, function, and interactions, making it a versatile tool for chemical and synthetic biology.

bioRxiv · May 8, 2019Cell Biology