Author

G. Geoghegan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

J. Simcox· 3 shared J. Cox· 2 shared J. Rutter· 2 shared S. Lee· 2 shared A. Abe· 1 shared A. Donato· 1 shared A. Hunger· 1 shared A. T. Cavanagh· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBiochemistry

J. Simcox

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3 papers

Recent·Most cited

Modulation of hepatic transcription factor EB activity during cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by Pla2g15

J. Davidson, R. Jain, T. Kizzar, G. Geoghegan, D. J. Nesbitt, A. T. Cavanagh, A. Abe, A. Hunger, X. Chao, I. James, D. Baldwin, R. Verma, K. L. Schueler, V. Hinkoka-Galcheva, S. Michorowska, , J. Simcox

The paper identifies TFEB regulation of BMP lipid catabolism via Pla2g15, showing increased BMP lipids in Pla2g15 knockout mice and cold intolerance upon TFEB knockdown.

bioRxiv · Nov 3, 2023Biochemistry

Mitochondrial pyruvate carrier is required for optimal brown fat thermogenesis

V. Panic, S. Pearson, J. Banks, T. S. Tippetts, S. Lee, J. Simcox, G. Geoghegan, C. Bensard, T. van Ry, W. L. Holland, S. Summers, J. Cox, G. Ducker, J. Rutter, C. Villanueva

This study shows that mitochondrial pyruvate carrier is essential for optimal brown fat thermogenesis, as its deletion impairs cold adaptation and alters metabolic pathways.

bioRxiv · Oct 29, 2019Biochemistry

Global analysis of plasma lipids identifies liver-derived acyl-carnitines as a fuel source for brown fat thermogenesis

J. Simcox, G. Geoghegan, J. A. Maschek, M. Pasquali, R. Miao, S. Lee, L. Jiang, I. Huck, A. Donato, U. Apte, N. Longo, J. Rutter, J. Cox, C. J. Villanueva

This study identifies liver-derived acyl-carnitines as a fuel source for brown fat thermogenesis, showing that cold exposure increases plasma acylcarnitine levels through hepatic HNF4 activation and that carnitine supplementation improves thermogenic response in aged mice.

bioRxiv · Apr 28, 2017Biochemistry