Author

K. L. Schueler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 5 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:gene regulatory network inference· 2 Research Focus:metabolism & bioenergetics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. D. Attie· 3 shared J. J. Coon· 3 shared D. J. Pagliarini· 2 shared E. Shishkova· 2 shared M. P. Keller· 2 shared N. M. Niemi· 2 shared A. Abe· 1 shared A. Hunger· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersBiochemistry

A. D. Attie

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Author profile →

5 papers

Recent·Most cited

Modulation of hepatic transcription factor EB activity during cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by Pla2g15

J. Davidson, R. Jain, T. Kizzar, G. Geoghegan, D. J. Nesbitt, A. T. Cavanagh, A. Abe, A. Hunger, X. Chao, I. James, D. Baldwin, R. Verma, K. L. Schueler, V. Hinkoka-Galcheva, S. Michorowska, , J. Simcox

The paper identifies TFEB regulation of BMP lipid catabolism via Pla2g15, showing increased BMP lipids in Pla2g15 knockout mice and cold intolerance upon TFEB knockdown.

bioRxiv · Nov 3, 2023Biochemistry

Pptc7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy

N. M. Niemi, L. R. Serrano, L. K. Muehlbauer, C. Balnis, K.-L. Kozul, E. H. Rashan, E. Shishkova, K. L. Schueler, M. P. Keller, A. D. Attie, J. Pagan, J. J. Coon, D. J. Pagliarini

This study shows that Pptc7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy, leading to metabolic defects and early lethality in mice.

bioRxiv · Feb 28, 2023Biochemistry

Novel regulators of islet function identified from genetic variation in mouse islet Ca2+ oscillations

C. Emfinger, L. E. Clark, B. S. Yandell, K. L. Schueler, S. Simonett, D. S. Stapleton, K. Mitok, M. J. Merrins, M. P. Keller, A. D. Attie

The paper identifies novel regulators of islet Ca2+ oscillations and insulin secretion by integrating genetic variation, Ca2+ dynamics, and protein abundance in mouse islets with human GWAS data.

bioRxiv · Nov 26, 2022 · PreprintBiochemistry

Synaptotagmin-9 and Tomosyn-1 molecular complex regulates Stx1A SNAREs to inhibit insulin secretion from pancreatic beta-cells

M. M. Rahman, A. Pathak, K. L. Schueler, H. A. Alsharif, A. N. Michl, J. Alexander, J.-a. Kim, E. R. Chapman, S. Bhatnagar

This study shows that synaptotagmin-9 inhibits insulin secretion by forming a complex with Tomosyn-1 and Stx1A, reducing SNARE complex formation in pancreatic beta-cells.

bioRxiv · Oct 20, 2022 · PreprintCell Biology

Pptc7 is an essential phosphatase for promoting mammalian mitochondrial metabolism and biogenesis

N. M. Niemi, G. M. Wilson, K. A. Overmyer, F.- N. Vogtle, D. C. Lohman, K. L. Schueler, A. D. Attie, C. Meisinger, J. J. Coon, D. J. Pagliarini

This study shows that Pptc7 is essential for mitochondrial metabolism and biogenesis, as its deletion in mice causes metabolic defects and early death.

bioRxiv · Sep 25, 2018Biochemistry