G. H. Koenderink

Reconstitution of cytolinker-mediated crosstalk between actin and vimentin

The paper engineers a recombinant actin-vimentin crosslinker, ACTIF, which forms composite bundles and stiffens actin-vimentin networks, demonstrating modularity in crosslinker design.

The Impact of the Local Mechanical Environment on Cell Shape and Chondrogenesis of Mesenchymal Stromal Cells in 3D Biomimetic Composite Materials

This study evaluates composite hydrogels of hyaluronan and fibrin to assess their impact on mesenchymal stromal cell shape and chondrogenesis in 3D environments.

Elucidating the role of water in collagen self assembly by isotopically modulating collagen hydration

This study investigates how water isotopes affect collagen self-assembly by comparing D2O and H2O, finding faster assembly and thinner fibrils in D2O due to reduced hydration.

Human septins in cells organize as octamer-based filaments mediating actin-membrane anchoring

This study shows that human septins form octamer-based filaments that mediate actin-membrane anchoring, as demonstrated through various imaging and biophysical techniques.

DisGUVery: a versatile open-source software for high-throughput image analysis of Giant Unilamellar Vesicles

DisGUVery automates GUV image analysis, enabling fast and consistent quantitative assessment across diverse imaging sources and experiments.

Cross-linkers at growing microtubule ends generate forces that drive actin transport

This paper shows that passive cross-linkers between actin and growing microtubules generate forces that transport actin filaments, revealing a new mechanism for actin remodeling.

The molecular structure and surface accumulation dynamics of hyaluronan at the water/air interface

This study investigates how hyaluronan's molecular weight affects its surface accumulation at water/air interfaces and its interaction with water molecules.

Membrane binding controls ordered self-assembly of animal septins

This study shows membrane binding enables fly septins to form ordered filamentous arrays, with C-terminal regions required for stacking.

Strong reduction of the chain rigidity of hyaluronan by selective binding of Ca2+ ions

This study investigates how calcium ions bind to hyaluronan, reducing its chain rigidity through specific molecular interactions.

Molecular packing structure of fibrin fibers resolved by X-ray scattering and molecular modeling

This study resolves the molecular packing structure of fibrin fibers using X-ray scattering and molecular modeling, revealing key structural features that explain their mechanical properties.

Revealing the molecular origins of fibrin’s elastomeric properties by in situ X-ray scattering

This study uses in situ X-ray scattering to reveal how fibrin's molecular structure contributes to its extensibility under shear strain, showing that fiber elongation arises from uncoiling of disordered C-peptide linkers.

Revealing the Assembly of Filamentous Proteins with Scanning Transmission Electron Microscopy

This paper introduces a semi-automated tracking algorithm to analyze molecular packing density of protein filaments using STEM images, revealing structural details of actin, microtubules, and collagen.

Frustrated binding of biopolymer crosslinkers

The paper measures crosslinker unbinding rates in actin networks using rheology and FRAP, finding a discrepancy between the two methods and attributing it to the mechanical properties of biopolymers.

Automated Tracking of Biopolymer Growth and Network Deformation with TSOAX

The paper introduces an open-source software tool for automated tracking of biopolymer networks in 2D and 3D using stretching open active contours, demonstrating its application in live cell studies.

Polarity sorting drives remodeling of actin-myosin networks

The paper investigates how myosin-driven polarity sorting remodels actin-myosin networks, showing that end-dwelling leads to contraction in quasi-2D networks.