M. Leptin

The Opto-inflammasome in zebrafish: a tool to study cell and tissue responses to speck formation and cell death

This paper introduces Opto-Asc, a light-controlled inflammasome tool in zebrafish to study speck formation and cell death, finding distinct morphological features of pyroptosis in periderm cells.

High-resolution line-scan Brillouin microscopy for live-imaging of mechanical properties during embryo development

This paper introduces a high-resolution line-scan Brillouin microscope for live-imaging mechanical properties during embryo development with reduced photo-toxicity.

Revisiting the origin of interleukin 1 (IL-1) based on biological activities of IL-1 in anamniotes and their sub-functionalization in amniotes

The paper investigates the evolutionary origin of IL-1 by comparing its biological activities in anamniotes and amniotes, finding sub-functionalization in mammals.

Optogenetic activators of apoptosis, necroptosis and pyroptosis for probing cell death dynamics and bystander cell responses

This paper develops optoCDEs, optogenetic tools to induce apoptosis, pyroptosis, and necroptosis, and uses them to study bystander cell responses to different cell death types.

Autophagy suppression by TORC1 maintains epithelial plasma membrane integrity and inhibits syncytium formation

The paper shows that autophagy, regulated by TORC1, maintains plasma membrane integrity and prevents syncytium formation during Drosophila wound healing.

Fluorescence-based 3D targeting of FIB-SEM acquisition of small volumes in large samples

The paper presents a method to precisely target FIB-SEM acquisition of fluorescently labeled cells in large samples using fluorescence preservation and confocal imaging.

An endosome-associated actin network involved in directed apical plasma membrane growth

The paper shows that late endosomes coordinate F-actin assembly to direct apical plasma membrane growth in Drosophila tracheal terminal cells.

Transcytosis via the late endocytic pathway as a cell morphogenetic mechanism

The paper demonstrates that endocytosis and late endosome trafficking regulate membrane allocation in Drosophila tracheal terminal cells during tubulogenesis.

Long-term in vivo imaging of Drosophila larvae

This paper describes a method for long-term in vivo imaging of Drosophila larvae using anaesthetisation, enabling high-resolution studies of various larval tissues and processes.

Polarity sorting drives remodeling of actin-myosin networks

The paper investigates how myosin-driven polarity sorting remodels actin-myosin networks, showing that end-dwelling leads to contraction in quasi-2D networks.

Dual Function For Tango1 In Secretion Of Bulky Cargo And In ER-Golgi Morphology

The paper shows that Tango1 is essential for secretion of bulky cargo and maintains ER-Golgi morphology, with defects in secretion and morphology being secondary to cargo retention.

A Theory That Predicts Behaviors Of Disordered Cytoskeletal Networks

The paper develops a theory to predict the contractile, expansile, or neutral behavior of isotropic cytoskeletal networks based on filament and connector properties.

Dynamics of ASC speck formation during skin inflammatory responses in vivo

The paper uses a live ASC reporter in zebrafish to study speck formation and pyroptosis in skin inflammation.