Author

G. H. Perdew

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Assay:metabolomics· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Assay:metagenomics· 1

Frequent Co-Authors

A. Annalora· 2 shared A. D. Patterson· 2 shared C. Marcus· 2 shared F. Dong· 2 shared I. A. Murray· 2 shared K. Gowda· 2 shared S. G. Amin· 2 shared A. Beck· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiochemistry

A. Annalora

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3 papers

Recent·Most cited

Complex chemical signals dictate Ah receptor activation through the gut-lung axis

F. Dong, I. A. Murray, A. Annalora, D. Coslo, D. Desai, K. Gowda, J. Yang, D. Wang, I. Koo, F. Hao, S. G. Amin, A. D. Patterson, C. Marcus, G. H. Perdew

The paper shows that urolithin A enhances AHR activity in gut and lung tissues by reducing clearance via CYP1A1/1B1, suggesting a role for dietary substrates in modulating AHR signaling through the gut-lung axis.

bioRxiv · Feb 22, 2023Biochemistry

Contribution of circulating host and microbial tryptophan metabolites towards Ah receptor activation

E. W. Morgan, F. Dong, A. Annalora, I. A. Murray, T. Wolfe, R. Erickson, K. Gowda, S. G. Amin, K. S. Petersen, P. M. Kris-Etherton, C. Marcus, S. T. Walk, A. D. Patterson, G. H. Perdew

This study identifies host and microbial tryptophan metabolites in serum that activate the AHR, showing host production dominates in mice despite microbial sources.

bioRxiv · Jan 26, 2023Biochemistry

Targeting the Pregnane X Receptor Using Microbial Metabolite Mimicry

Z. Dvorak, F. Felix Kopp, C. M. Costello, J. S. Kemp, H. Li, A. Vrzalova, M. Stepankova, I. Iveta Bartonkov, K. Poulikova, B. Vyhlidalova, L. U. Nordstroem, C. Karunaratne, H. Ranhotra, K. S. Mun, A. P. Naren, , R. B. Sartor

This paper develops FKK6, a non-cytotoxic PXR agonist derived from microbial metabolite mimicry, which reduces inflammation and validates the strategy for drug discovery.

bioRxiv · Jan 3, 2020Biochemistry