Author

D. Desai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Biochemistry· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:metabolomics· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. S. Khalil· 2 shared C. Ching· 2 shared I. Sutradhar· 2 shared M. H. Zaman· 2 shared Z. Heins· 2 shared A. A. Alli· 1 shared A. Annalora· 1 shared A. Baby· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersBioengineering

A. S. Khalil

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

MYBPC3 D389V Variant Induces Hypercontractility in Cardiac Organoids

D. Desai, T. Song, R. Singh, A. Baby, J. McNamara, L. Green, P. Nabavizadeh, M. Ericksen, S. Bazrafshan, S. Natesan, S. Sadayappan

This study investigates the molecular mechanisms of HCM caused by the MYBPC3 D389V variant using cardiac organoids and shows hypercontractility and mitochondrial defects that are rescued by a myosin inhibitor.

bioRxiv · May 29, 2024 · PreprintCell Biology

Complex chemical signals dictate Ah receptor activation through the gut-lung axis

F. Dong, I. A. Murray, A. Annalora, D. Coslo, D. Desai, K. Gowda, J. Yang, D. Wang, I. Koo, F. Hao, S. G. Amin, A. D. Patterson, C. Marcus, G. H. Perdew

The paper shows that urolithin A enhances AHR activity in gut and lung tissues by reducing clearance via CYP1A1/1B1, suggesting a role for dietary substrates in modulating AHR signaling through the gut-lung axis.

bioRxiv · Feb 22, 2023Biochemistry

Effects of Antibiotic Interaction on Antimicrobial Resistance Development in Wastewater

I. Sutradhar, C. Ching, D. Desai, Z. Heins, A. S. Khalil, M. H. Zaman

This study investigates how antibiotic interactions in wastewater affect antimicrobial resistance development in E. coli, finding that synergistic interactions suppress resistance while antagonistic interactions show ratio-dependent resistance development.

bioRxiv · Feb 10, 2023Bioengineering

Kidney tubular epithelial cell ferroptosis links glomerular injury to tubulointerstitial pathology in lupus nephritis

A. A. Alli, D. Desai, A. Elshika, L. Morel, M. Conrad, B. Proneth, W. Clapp, C. Atkinson, M. Segal, L. Searcy, N. Denslow, S. Bolisetty, B. Mehrad, Y. Scindia

This study shows ferroptosis occurs in kidney tubules of lupus nephritis patients and mice, and a drug can reduce it, suggesting new treatment options.

bioRxiv · May 26, 2022Immunology

Computational Model to Quantify the Growth of Antibiotic Resistant Bacteria in Wastewater

I. Sutradhar, C. Ching, D. Desai, M. Suprenant, E. Briars, Z. Heins, A. S. Khalil, M. H. Zaman

The paper develops a computational model to predict antibiotic resistant bacteria growth in wastewater, finding horizontal gene transfer and antibiotic interactions drive resistance more than chromosomal mutations.

bioRxiv · Oct 9, 2020Bioengineering