Author

G. I. Smith

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:metabolomics· 2

Frequent Co-Authors

S. Klein· 3 shared A. J. Lutkewitte· 2 shared G. J. Patti· 2 shared J. M. Singer· 2 shared J. R. Brestoff· 2 shared A. LaPoint· 1 shared A. S. Kim· 1 shared B. Finck· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersPhysiology

S. Klein

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Author profile →

3 papers

Recent·Most cited

MXRA8 promotes adipose tissue whitening to drive obesity

W. Jia, R. Giwa, J. R. Moley, G. I. Smith, M. C. Petersen, R. L. Field, O. Abousaway, A. S. Kim, S. R. Coffey, S. Varnum, J. M. Wright, X. Zhang, S. Krysa, I. J. Lodhi, N. A. Abumrad, , J. R. Brestoff

This study identifies MXRA8 as a promoter of adipose tissue whitening that drives obesity, showing its role in reducing UCP1 expression and protecting against obesity in mice.

bioRxiv · Jan 31, 2024 · PreprintPhysiology

Adipocyte lipin 1 is positively associated with metabolic health in humans and regulates systemic metabolism in mice.

A. LaPoint, J. M. Singer, D. Ferguson, T. M. Shew, K. RenKemeyer, H. Palacios, R. Field, M. Shankaran, G. I. Smith, J. Yoshino, M. He, G. J. Patti, M. Hellerstein, S. Klein, J. R. Brestoff, , A. J. Lutkewitte

The paper shows that lower adipose lipin 1 in humans correlates with metabolic issues, and mice lacking adipocyte lipin 1 develop metabolic disorders.

bioRxiv · Feb 1, 2023 · PreprintPhysiology

Silencing alanine transaminase 2 in diabetic liver attenuates hyperglycemia by reducing gluconeogenesis from amino acids

M. R. Martino, M. Gutierrez-Aguilar, N. K. H. Yiew, A. J. Lutkewitte, J. M. Singer, K. S. McCommis, G. I. Smith, K. Cho, J. A. Fletcher, S. Klein, G. J. Patti, S. C. Burgess, B. N. Finck

This study shows that silencing ALT2 in diabetic liver reduces hyperglycemia by decreasing amino acid-derived gluconeogenesis.

Cell Reports · Apr 1, 2022Peer-reviewedPhysiology