S. C. Burgess

Ubiquinone deficiency drives reverse electron transport to disrupt hepatic metabolic homeostasis in obesity

The paper shows that ubiquinone deficiency in obesity leads to reverse electron transport, increasing mROS and disrupting hepatic metabolic homeostasis.

Effects of hepatic mitochondrial pyruvate carrier deficiency on de novo lipogenesis and glycerol-mediated gluconeogenesis in mice

This study investigates how liver mitochondrial pyruvate carrier deficiency affects de novo lipogenesis and glycerol-mediated gluconeogenesis in mice, finding impaired DNL but no reduction in intrahepatic lipid and unchanged glucose levels despite reduced glycerol metabolism.

Larval and adult traits coevolve in response to coastal oceanography to shape marine dispersal kernels

The paper models how coastal ocean currents influence the evolution of larval and adult traits, leading to different dispersal kernel outcomes.

Loss of hepatic phosphoenolpyruvate carboxykinase 1 dysregulates metabolic responses to acute exercise but enhances adaptations to exercise training in mice

This study shows that loss of hepatic PEPCK1 impairs acute exercise glucose regulation but improves liver lipid reduction and muscle mitochondrial adaptations with exercise training in mice.

Silencing alanine transaminase 2 in diabetic liver attenuates hyperglycemia by reducing gluconeogenesis from amino acids

This study shows that silencing ALT2 in diabetic liver reduces hyperglycemia by decreasing amino acid-derived gluconeogenesis.