G. M. Church

The paper isolates two novel marine cyanobacteria from CO2-rich environments, characterizes their rapid growth and high biomass density, and suggests their potential for CO2-based bioproduction.

The paper develops a method to improve EV isolation by quantitatively measuring and removing free proteins and lipoproteins using Simoa assays and chromatography.

This study develops a multiplex CRISPR-Cas system targeting ASF virus genomic loci, demonstrating resistance in gene-edited pigs and potential applications in agriculture and biomedicine.

The paper introduces a DNA nanoscope that spatially maps and uniquely identifies over 100 molecular features with nanometer accuracy using DNA barcoding and sequencing.

This study identifies 33 SARS-CoV-2 peptides that mimic human proteins, revealing potential for immune evasion and MHC detection.

This paper introduces a high-throughput method called SEER to discover efficient single-stranded DNA-annealing proteins (SSAPs) for bacterial recombineering, identifying variants that significantly improve genome editing efficiency in multiple bacterial species.

This paper introduces a DNA-based method to enhance multiplexed protein imaging using primary antibodies, demonstrating its application in cultured cells and mouse retina sections.

The paper shows that injecting differentiated iPSCs into subfertile mice restores reproductive hormone synthesis and fertility.

This paper introduces Immuno-SABER, a method for highly multiplexed protein imaging that overcomes limitations in sensitivity and throughput.

This paper reports the adaptive evolution of a genomically recoded E. coli strain to improve its fitness and identifies mutations that enhance its growth in defined media.

This paper introduces DNA-Exchange-Imaging, a method for rapid, highly multiplexed in situ protein visualization, achieving sub-20 nm resolution and reducing imaging time from days to minutes.

The paper evaluates the PURE system for in vitro protein synthesis, identifying factors affecting protein yield and activity, and proposes optimizations to improve performance.

This study investigates how the PKAL205R mutation in Cushing’s Syndrome alters PKA substrate specificity using a proteomic peptide library approach.