Loss of RNF43/ZNRF3 predisposes to Hepatocellular carcinoma by impairing liver regeneration and altering liver fat metabolism
G. Mastrogiovanni, C. Pacini, S. Kakava, R. Arnes-Benito, C. R. Bradshaw, S. Davies, K. Saeb-Parsy, B.-K. Koo, M. Huch
This study shows that loss of RNF43/ZNRF3 leads to liver cancer by disrupting lipid metabolism and impairing liver regeneration in mice, with similar effects observed in human patients.
bioRxiv · Sep 25, 2020 · PreprintCancer Biology