M. Huch

ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin

This study shows ICAM-1 nanoclusters control hepatic epithelial cell polarity through actomyosin regulation, independent of leukocyte adhesion.

Fasting reverses drug-resistance in hepatocellular carcinoma through p53-dependent metabolic synergism

This study shows that fasting enhances the effectiveness of sorafenib in hepatocellular carcinoma by reversing drug resistance through p53-dependent metabolic changes.

Human liver organoids; a patient-derived primary model for HBV Infection and Related Hepatocellular Carcinoma

This paper establishes human liver organoids as a model for HBV infection and HCC, showing they support viral replication, produce infectious HBV, and exhibit cancer-related gene signatures.

Loss of RNF43/ZNRF3 predisposes to Hepatocellular carcinoma by impairing liver regeneration and altering liver fat metabolism

This study shows that loss of RNF43/ZNRF3 leads to liver cancer by disrupting lipid metabolism and impairing liver regeneration in mice, with similar effects observed in human patients.

Long-term live imaging of epithelial organoids and corresponding multiscale analysis reveal high heterogeneity and identify core regulatory principles

The paper uses multiscale imaging and analysis of organoids to identify core regulatory principles of morphogenesis and reveal high heterogeneity in cell organization.