ImmunologybioRxivPreprint
Stress-Mediated Attenuation of Translation Undermines T Cell Tumor Control
B. P. Riesenberg, E. G. Hunt, M. D. Tennant…·J. E. Thaxton
This study shows that solid tumor microenvironment stress reduces T cell protein translation via the UPR and p-eIF2, and that proteasome stimulation can reverse this effect to enhance antitumor immunity.