J. E. Thaxton

Tirzepatide restricts obesity-related tumor growth by reversing metabolic dysregulation and rescuing CD8+ T cell function

This study shows tirzepatide reduces obesity-related tumor growth by improving metabolism and restoring CD8+ T cell function without directly targeting cancer cells.

Acetyl-CoA Carboxylase Obstructs CD8+ T-Cell Lipid Utilization and Energy Synthesis in the Tumor Microenvironment

This study shows that acetyl-CoA carboxylase (ACC) activity in T cells within the tumor microenvironment inhibits lipid utilization and energy synthesis, and its restriction enhances T cell survival and antitumor function.

Adaptive IRE1 Signaling Elicits T Cell Metabolic Remodeling and Tumor Control

This study shows that enhancing the adaptive IRE1 UPR pathway in T cells improves tumor control by reducing mitochondrial toxicity and chronic ER stress.

The degree of T cell stemness differentially impacts the potency of adoptive cancer immunotherapy in a Lef-1 and Tcf-1 dependent manner.

This study shows that varying levels of PI3Kδ pathway inhibition affect T cell stemness, with higher stemness improving cancer immunotherapy outcomes in multiple tumor models.

Atlas-Guided Discovery of Transcription Factors for T Cell Programming

The paper identifies transcription factors driving distinct CD8+ T cell states and shows their impact on tumor control and immunotherapy.

Stress-Mediated Attenuation of Translation Undermines T Cell Tumor Control

This study shows that solid tumor microenvironment stress reduces T cell protein translation via the UPR and p-eIF2, and that proteasome stimulation can reverse this effect to enhance antitumor immunity.

B cells imprint adoptively transferred CD8+ T cells with enhanced tumor immunity

This study shows that CpG-mediated expansion with B cells enhances CD8+ T cell tumor immunity by inducing a unique proteomic signature and specific surface markers.