Acetyl-CoA Carboxylase Obstructs CD8+ T-Cell Lipid Utilization and Energy Synthesis in the Tumor Microenvironment
E. G. Hunt, K. E. Hurst, B. P. Riesenberg, A. S. Kennedy, E. J. Gandy, A. M. Andrews, E. D. Wallace, P. Gao, M. Coleman, J. E. Thaxton
This study shows that acetyl-CoA carboxylase (ACC) activity in T cells within the tumor microenvironment inhibits lipid utilization and energy synthesis, and its restriction enhances T cell survival and antitumor function.
bioRxiv · Nov 16, 2023 · PreprintImmunology