Stress-Mediated Attenuation of Translation Undermines T Cell Tumor Control
B. P. Riesenberg, E. G. Hunt, M. D. Tennant, K. E. Hurst, A. M. Andrews, L. R. Leddy, D. M. Neskey, E. G. Hill, G. O. R. Rivera, C. M. Paulos, P. Gao, J. E. Thaxton
This study shows that solid tumor microenvironment stress reduces T cell protein translation via the UPR and p-eIF2, and that proteasome stimulation can reverse this effect to enhance antitumor immunity.
bioRxiv · Jan 31, 2022 · PreprintImmunology