G. S. Hotamisligil

This study shows that hepatic IRE1 protects against septic cardiac failure by maintaining lipid metabolic balance, independent of inflammation.

The paper shows that ubiquinone deficiency in obesity leads to reverse electron transport, increasing mROS and disrupting hepatic metabolic homeostasis.

This study shows that ATGL is not required for lipolysis-stimulated FABP4 secretion from adipocytes, which can occur via sympathetic signaling.

This study identifies endothelial cells as the main source of baseline circulating FABP4 and shows they are required for lipolysis-driven insulin secretion.

The paper uses high-resolution 3D imaging to show that subcellular organization in liver cells changes with obesity, affecting metabolism.

This study identifies IP3R over-activation in adipocytes as a key mechanism linking obesity, inflammation, and insulin resistance, suggesting therapeutic targeting of Ca2+ homeostasis.

The study measures superoxide/H2O2 production in mitochondria from BTHS mice and finds no overall increase, except for a specific site in skeletal muscle.