Author

G. Parlakgul

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:metabolism & bioenergetics· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

A. P. Arruda· 3 shared G. S. Hotamisligil· 3 shared E. Cagampan· 2 shared E. Guney· 2 shared Y. Lee· 2 shared C. Rosique· 1 shared C. S. Xu· 1 shared E. Tsaousidou· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersBiochemistry

A. P. Arruda

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Author profile →

3 papers

Recent·Most cited

Ubiquinone deficiency drives reverse electron transport to disrupt hepatic metabolic homeostasis in obesity

R. L. S. Goncalves, Z. B. Wang, K. E. Inouye, Y. G. Lee, X. Fu, J. Saksi, C. Rosique, G. Parlakgul, A. P. Arruda, T. S. Hui, M. C. Loperena, S. C. Burgess, I. Graupera, G. S. Hotamisligil

The paper shows that ubiquinone deficiency in obesity leads to reverse electron transport, increasing mROS and disrupting hepatic metabolic homeostasis.

bioRxiv · Feb 21, 2023 · PreprintBiochemistry

High resolution 3D imaging of liver reveals a central role for subcellular architectural organization in metabolism

G. Parlakgul, A. P. Arruda, E. Cagampan, S. Pang, E. Guney, Y. Lee, H. F. Hess, C. S. Xu, G. S. Hotamisligil

The paper uses high-resolution 3D imaging to show that subcellular organization in liver cells changes with obesity, affecting metabolism.

bioRxiv · Nov 18, 2020Cell Biology

Aberrant Ca2+ homeostasis in adipocytes links inflammation to metabolic dysregulation in obesity

E. Guney, A. P. Arruda, G. Parlakgul, E. Cagampan, N. Min, Y. Lee, L. Greene, E. Tsaousidou, K. Inouye, M. S. Han, R. J. Davis, G. S. Hotamisligil

This study identifies IP3R over-activation in adipocytes as a key mechanism linking obesity, inflammation, and insulin resistance, suggesting therapeutic targeting of Ca2+ homeostasis.

bioRxiv · Oct 28, 2020Physiology