G. Y. Lee

FABP4 as a Therapeutic Host Target Controlling SARS-CoV2 Infection

This study identifies FABP4 as a host target that modulates SARS-CoV-2 infection, showing that its inhibition reduces viral replication and lung damage in infected hamsters.

Single missense mutations in Vi capsule synthesis genes confer hypervirulence to Salmonella Typhi

The paper identifies single missense mutations in Vi capsule synthesis genes that confer hypervirulence to Salmonella Typhi by altering capsule length or acetylation.

ATGL is differentially required for adipocyte FABP4 secretion in vivo and ex vivo

This study shows that ATGL is not required for lipolysis-stimulated FABP4 secretion from adipocytes, which can occur via sympathetic signaling.

Endothelial FABP4 constitutes the majority of basal circulating hormone levels and regulates lipolysis-driven insulin secretion

This study identifies endothelial cells as the main source of baseline circulating FABP4 and shows they are required for lipolysis-driven insulin secretion.

The SARS-CoV-2 accessory protein Orf3a is not an ion channel, but does interact with trafficking proteins

This paper shows SARS-CoV-2 Orf3a is not an ion channel but interacts with trafficking proteins, while SARS-CoV-1 Orf3a does not.

The molecular basis of extensively drug-resistant Salmonella Typhi isolates from pediatric septicemia patients

This study characterizes antibiotic resistance gene signatures in extensively drug-resistant Salmonella Typhi isolates from pediatric septicemia patients to inform molecular detection methods and control strategies.

Novel Paju Apodemus Paramyxovirus 1 and 2, Harbored by Apodemus agrarius in The Republic of Korea

This study identifies two novel paramyxoviruses, PAPV-1 and PAPV-2, from Apodemus agrarius rodents in Korea, revealing distinct genome structures and zoonotic potential.