A single amino acid substitution in PB1 of pandemic H1N1 with A/Ann Arbor/6/60 master donor virus mutations as a novel live-attenuated influenza virus vaccine
A. Nogales, J. Steel, W.-C. Liu, A. C. Lowen, L. Rodriguez, K. Chiem, A. Cox, A. Garcia-Sastre, R. Albrecht, S. Dewhurst, L. Martinez-Sobrido
This paper shows that a single amino acid change in the PB1 protein of the pandemic H1N1 virus can create a live-attenuated vaccine with reduced pathogenicity and transmission.
bioRxiv · Jan 7, 2022 · PreprintMicrobiology