Author

K. Ganti

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 9

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:host-pathogen & immune response· 9 Organism:human· 3 Organism:mouse· 3 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. C. Lowen· 9 shared L. M. Ferreri· 4 shared C.-Y. Lee· 3 shared G. K. Delima· 3 shared K. E. Holmes· 3 shared A. Bagga· 2 shared B. Manicassamy· 2 shared D. R. Perez· 2 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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9 shared papersMicrobiology

A. C. Lowen

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Author profile →

9 papers

Recent·Most cited

Viral expansion after transfer is a primary driver of influenza A virus transmission bottlenecks

K. E. Holmes, D. VanInsberghe, L. M. Ferreri, B. Elie, K. Ganti, C.-Y. Lee, A. C. Lowen

This study identifies viral expansion after transfer as a key factor in influenza A virus transmission bottlenecks, showing that diversity declines rapidly post-infection.

bioRxiv · Nov 19, 2023Microbiology

Influenza A virus coinfection dynamics are shaped by distinct virus-virus interactions within and between cells

G. K. Delima, K. Ganti, K. E. Holmes, J. R. Shartouny, A. C. Lowen

This study investigates how influenza A virus coinfection dynamics are influenced by virus-virus interactions within and between cells, finding both beneficial intracellular interactions and antagonistic host-level competition.

bioRxiv · Nov 27, 2022Microbiology

Influenza A virus reassortment in mammals gives rise to genetically distinct within-host sub-populations

K. Ganti, A. Bagga, S. Carnaccini, L. M. Ferreri, G. Geiger, J. Caceres, B. A. Seibert, Y. Li, L. Wang, T. Kwon, Y. Li, I. Morozov, W. Ma, J. A. Richt, D. R. Perez, , A. C. Lowen

This study examines reassortment dynamics of influenza A virus in guinea pigs, ferrets, and swine, finding reassortment is common but more frequent in ferrets and guinea pigs than swine, with spatial compartmentalization observed.

bioRxiv · Feb 8, 2022 · PreprintMicrobiology

Timing of exposure is critical in a highly sensitive model of SARS-CoV-2 transmission

K. Ganti, A. C. Lowen, L. M. Ferreri, C.-Y. Lee, C. R. Bair, G. K. Delima, K. E. Holmes, M. S. Suthar

This study shows that the timing of SARS-CoV-2 exposure, particularly during peak viral load, is the strongest determinant of transmission success in golden Syrian hamsters.

bioRxiv · Dec 8, 2021Microbiology

Host Factor Rab11a is Critical for Efficient Assembly of Influenza A Virus Genomic Segments

J. Han, K. Ganti, V. K. Sali, C. Twigg, Y. Zhang, S. Manivasagam, C.-Y. Liang, O. A. Vogel, I. Huang, S. N. Emmanuel, J. Plung, L. Radoshevich, J. T. Perez, A. C. Lowen, B. Manicassamy

This study identifies Rab11a as a critical host factor for influenza A virus genome assembly by facilitating vRNP congregation and specific interactions.

bioRxiv · Apr 6, 2021Microbiology

Avian influenza A viruses reassort and diversify differently in mallards and mammals

K. Ganti, A. Bagga, J. DaSilva, S. S. Shepard, J. R. Barnes, S. A. Shriner, K. Koelle, A. C. Lowen

This study compares avian influenza A virus reassortment in mallards and guinea pigs, finding higher reassortant frequencies and diversity in mallards.

bioRxiv · Feb 8, 2021Microbiology

Rab11a mediates cell-cell spread and reassortment of influenza A virus genomes via tunneling nanotubes.

K. Ganti, J. Han, B. Manicassamy, A. C. Lowen

This paper identifies Rab11a's role in facilitating cell-cell spread of influenza A virus genomes via tunneling nanotubes, enabling genome reassortment and bypassing extracellular barriers.

bioRxiv · Jan 20, 2021Microbiology

Collective interactions augment influenza A virus replication in a host-dependent manner

K. L. Phipps, K. Ganti, N. T. Jacobs, C.-Y. Lee, S. Carnacinni, M. C. White, M. Manandhar, B. E. Pickett, G. S. Tan, L. M. Ferreri, D. R. Perez, A. C. Lowen

The paper shows that influenza A virus requires collective interactions for replication in mammalian cells but not in avian cells, with the PA gene segment playing a key role.

bioRxiv · Mar 7, 2020Microbiology

Dysregulation of M segment gene expression contributes to influenza A virus host restriction

B. M. Calderon, S. Danzy, G. K. Delima, N. T. Jacobs, K. Ganti, M. R. Hockman, G. L. Conn, A. C. Lowen, J. Steel

This study identifies dysregulation of M segment gene expression, particularly M2 overexpression, as a key factor in avian influenza A virus restriction in mammalian hosts.

PLOS Pathogens · Aug 15, 2019Peer-reviewedMicrobiology