Author

G. Scanavachi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:imaging· 2 Organism:mouse· 2 Approach:deep learning· 1

Frequent Co-Authors

T. Kirchhausen· 4 shared A. Saminathan· 3 shared A. Sanyal· 2 shared E. Somerville· 2 shared N. S. Hatzakis· 2 shared A. Geneid· 1 shared A. J. B. Kreutzberger· 1 shared A. J. Nielsen· 1 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersCell Biology

T. Kirchhausen

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Constitutive Endolysosomal Perforation in Neurons allows Induction of alpha-Synuclein Aggregation by Internalized Pre-Formed Fibrils

A. Sanyal, G. Scanavachi, E. Somerville, A. Saminathan, A. Nair, A. Oikonomou, N. S. Hatzakis, T. Kirchhausen

The paper shows that neurons have constitutive endolysosomal perforations enabling internalized alpha-synuclein fibrils to induce aggregation, and inhibiting PIKfyve kinase reduces this effect.

bioRxiv · Dec 30, 2023 · PreprintCell Biology

Deep learning assisted single particle tracking for automated correlation between diffusion and function

J. Kaestel-Hansen, M. de Sautu, A. Saminathan, G. Scanavachi, R. F. B. D. C. Correia, A. J. Nielsen, S. V. Bleshoy, W. Boomsma, T. Kirchhausen, N. S. Hatzakis

This paper introduces DeepSPT, a deep learning framework that automates the analysis of sub-cellular diffusion to infer functional information, achieving high accuracy in identifying endosomal structures during viral infections.

bioRxiv · Nov 16, 2023Biophysics

Temporal Dynamics and Stoichiometry in Notch Signaling - from Notch Synaptic Complex Formation to NICD Nuclear Entry

L. Tveriakhina, G. Scanavachi, E. D. Egan, R. B. D. C. Correia, A. P. Martin, J. M. Rogers, J. S. Yodh, J. C. Aster, T. Kirchhausen, S. C. Blacklow

This study tracks Notch and Delta interactions in real-time, showing 1:1 stoichiometry at synapses and NICD nuclear entry after 45 minutes, inhibited by signaling blockers.

bioRxiv · Sep 27, 2023 · PreprintCell Biology

SARS-CoV-2 requires acidic pH to infect cells

A. J. B. Kreutzberger, A. Sanyal, A. Saminathan, L.-M. Bloyet, S. Stumpf, Z. Liu, R. Ojha, M. T. Patjas, A. Geneid, G. Scanavachi, C. A. Doyle, E. Somerville, R. Bango Da Cunha Correira, G. Di Caprio, S. Toppila-Salmi, , T. Kirchhausen

This study shows SARS-CoV-2 requires acidic pH for membrane fusion and genome release, even after proteolytic cleavage by furin or TMPRSS2.

bioRxiv · Jun 9, 2022Microbiology