A. Sanyal

Evaluation of extraction solvents for untargeted metabolomics to decipher the dissolved organic matter of Antarctic cryoconite holes

This study evaluates solvent combinations for untargeted metabolomics to analyze dissolved organic matter in Antarctic cryoconite holes, finding that specific solvent mixtures enhance metabolite detection.

Loss of TIM4-Dependent Efferocytosis in Kupffer CellsPromotes Liver Fibrosis in Nonalcoholic Steatohepatitis

This study shows that loss of TIM4 in Kupffer cells impairs efferocytosis of apoptotic hepatocytes in NASH, promoting liver fibrosis, and that restoring TIM4 reduces fibrosis.

Constitutive Endolysosomal Perforation in Neurons allows Induction of alpha-Synuclein Aggregation by Internalized Pre-Formed Fibrils

The paper shows that neurons have constitutive endolysosomal perforations enabling internalized alpha-synuclein fibrils to induce aggregation, and inhibiting PIKfyve kinase reduces this effect.

Unraveling molecular basis for reduced neuraminidase inhibitors susceptibility in highly pathogenic avian influenza A (H5N1) viruses isolated from chickens in India

This study identifies mutations in H5N1 avian influenza viruses that confer resistance to neuraminidase inhibitors, revealing their molecular mechanisms and implications for antiviral strategies.

Host-pathogen-vector continuum in a changing landscape: Drivers of Bartonella prevalence and evidence of historic spillover in a multi-host community

The paper investigates Bartonella prevalence in small mammals and ectoparasites, finding ectoparasites drive transmission and evidence of historic spillover.

Aberrant phase separation is a common killing strategy of positively charged peptides in biology and human disease

The paper identifies a common toxic mechanism in positively charged peptides across species and develops a machine learning tool to detect it.

Bacopa monnieri phytochemicals regulate fibroblast cell migration via modulation of focal adhesions

This study shows Bacopa monnieri extract enhances fibroblast migration through focal adhesion modulation, improving wound healing.

Deep neural network automated segmentation of cellular structures in volume electron microscopy

This paper introduces ASEM, a deep learning pipeline for automated segmentation of cellular structures in electron microscopy, demonstrating its effectiveness in identifying various organelles and membrane structures.

A metagenomic view on fungal diversity in freshwater lakes

The paper analyzes metagenomic data from freshwater lakes to study fungal and Oomycota diversity and identifies environmental factors influencing their distribution.

SARS-CoV-2 requires acidic pH to infect cells

This study shows SARS-CoV-2 requires acidic pH for membrane fusion and genome release, even after proteolytic cleavage by furin or TMPRSS2.

Poly(A)-binding protein is an ataxin-2 chaperone that emulsifies biomolecular condensates.

The paper identifies a conserved 14aa sequence in ataxin-2 that acts as a condensation switch and reveals poly(A)-binding proteins as RNA-dependent chaperones that regulate this switch.

Synergistic block of SARS-CoV-2 infection by combined drug inhibition of the host entry factors PIKfyve kinase and TMPRSS2 protease

This study finds that combining apilimod and camostat mesylate or nafamostat mesylate significantly enhances inhibition of SARS-CoV-2 infection in vitro.

Not dead yet: Diatom resting spores can survive in nature for several millennia.

This paper revives ancient diatom resting spores up to 7200 years old and extracts DNA to study long-term environmental adaptation.

Alpha-Synuclein is a Target of Fic-mediated Adenylylation/AMPylation: Implications for Parkinson’s Disease

The paper identifies alpha-Synuclein as a target of HYPE-mediated adenylylation, showing it reduces Syn aggregation and ER stress in Parkinson’s disease models.

Kinetic And Structural Parameters Governing Fic-Mediated Adenylylation/AMPylation of the Hsp70 chaperone, BiP/GRP78

This study investigates the kinetic and structural parameters of HYPE-mediated adenylylation/AMPylation of BiP/GRP78, revealing site-specific effects on ATPase activity and substrate recognition.