G. Seebohm

Altered dynamics of ATP synthase cause functional irregularities in senescent hiPS-cardiomyocytes

The paper investigates altered ATP synthase dynamics in senescent hiPS-cardiomyocytes, linking structural changes in mitochondria to reduced enzyme activity and impaired cardiac function.

Tagging of Exo70 at the N-terminus compromises its assembly with the exocyst complex and changes its spatiotemporal behavior at the plasma membrane

This paper shows that N-terminal tagging of Exo70 disrupts its assembly with the exocyst complex and alters its spatiotemporal behavior at the plasma membrane.

Mdivi-1 affects neuronal activity by inhibition of Complex I and respiratory supercomplex assembly

This paper identifies that Mdivi-1 inhibits mitochondrial complex I, disrupts supercomplex assembly, and impairs neuronal activity by affecting ATP production and calcium homeostasis.

An Activator Locks Kv7.1 Channels Open by Electro-Mechanical Uncoupling and Allosterically Modulates its Pore with similarity to phosphatidylinositol-4,5-bisphosphat

This study identifies two independent mechanisms by which (R)-L3 activates Kv7.1 channels, involving allosteric modulation of the pore and electro-mechanical uncoupling.

Two-stage electro-mechanical coupling of a Kv channel in voltage-dependent activation

The paper identifies a two-stage electro-mechanical coupling mechanism in KV7.1 channels, where VSD transitions through intermediate and activated states to trigger pore opening.