Author

M. Tarek

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:mechanistic / dynamical model· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. DEYAWE KONGMENECK· 3 shared M. A. Kasimova· 2 shared A. Noack· 1 shared A. R. Goldman· 1 shared A. Savarino· 1 shared A. Singh· 1 shared B. Lucic· 1 shared C. Elrod· 1 shared

Activity by Year

2019-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersBiophysics

A. DEYAWE KONGMENECK

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Molecular determinants of the modulation of the VSD-PD coupling mechanism of the KV7.1 channel by the KCNE1 ancillary subunits

A. DEYAWE KONGMENECK, M. Kasimova, M. TAREK

The paper investigates how KCNE1 subunits modulate the coupling between the voltage sensor and pore domain of KV7.1 channels using molecular dynamics simulations.

bioRxiv · Sep 1, 2021 · PreprintBiophysics

Modulation of the IKS channel by PIP2 requires two binding sites per monomer

A. Deyawe Kongmeneck, M. A. Kasimova, M. Tarek

The paper presents molecular models of the KV7.1/KCNE1 complex in different states and shows that two PIP2 lipids are required per monomer to stabilize each state.

bioRxiv · Jan 13, 2021Biophysics

Glycolysis downregulation is a hallmark of HIV-1 latency and sensitizes infected cells to oxidative stress

I. L. Shytaj, F. A. Procopio, M. Tarek, I. Carlon-Andres, H.-Y. Tang, A. R. Goldman, M. Munshi, M. Forcato, K. Leskov, F. Ye, B. Lucic, N. Cruz, A. Singh, S. Bicciato, S. Padilla-Parra, , A. Savarino

The paper shows that glycolysis downregulation is a hallmark of HIV-1 latency and that targeting antioxidant pathways can reactivate latent HIV-1.

bioRxiv · Dec 30, 2020Immunology

On the permeability of cell membranes subjected to lipid oxidation

D. Wiczew, N. Szulc, M. TAREK

This paper quantifies how secondary lipid oxidation contributes to long-lived membrane permeability after electroporation, showing that lipid oxidation patches form persistent pores and that cholesterol prolongs their lifetime.

bioRxiv · Nov 30, 2020Biophysics

Accelerated Predictive Healthcare Analytics with Pumas, A High Performance Pharmaceutical Modeling and Simulation Platform

C. V. Rackauckas, Y. Ma, A. Noack, V. Dixit, P. Mogensen, C. Elrod, M. Tarek, S. Byrne, S. Maddhashiya, J. B. S. Calderon, M. Hatherly, J. Nyberg, J. Gobburu, V. Ivaturi

The paper introduces Pumas, a high-performance platform for pharmacometric modeling, showing significant performance improvements in drug development and precision medicine.

bioRxiv · Nov 28, 2020 · PreprintPharmacology & Toxicology

Two-stage electro-mechanical coupling of a Kv channel in voltage-dependent activation

P. Hou, P. W. Kang, A. Deyawe Kongmeneck, N.-D. Yang, Y. Liu, J. Shi, X. Xu, K. M. White, M. A. Zaydman, M. A. Kasimova, G. Seebohm, L. Zhong, X. Zou, M. Tarek, J. Cui

The paper identifies a two-stage electro-mechanical coupling mechanism in KV7.1 channels, where VSD transitions through intermediate and activated states to trigger pore opening.

bioRxiv · Oct 9, 2019Biophysics