Author

G. Seumois

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 8

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 7 Approach:experimental assay· 7 Organism:human· 6 Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Research Focus:cell-cell communication· 3 Research Focus:differential expression· 3 Organism:mouse· 3

Frequent Co-Authors

P. Vijayanand· 8 shared A. Sette· 5 shared B. Peters· 3 shared C. Ottensmeier· 3 shared C. S. Lindestam Arlehamn· 3 shared A. L. R. Premlal· 2 shared C. Ramirez-Suastegui· 2 shared D. Weiskopf· 2 shared

Activity by Year

2018-2021 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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8 shared papersImmunology

P. Vijayanand

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Transcriptomes and metabolism define mouse and human MAIT cell heterogeneity

S. Chandra, G. Ascui, T. Riffelmacher, A. Chawla, C. Ramirez-Suastegui, V. C. Castelan, G. Seumois, H. Simon, M. P. Murray, G.-Y. Seo, A. L. R. Premlal, G. Verstichel, Y. Li, C.-H. Lin, J. Greenbaum, , M. Kronenberg

This study identifies MAIT cell heterogeneity in mice and humans through single-cell RNA sequencing and metabolic analysis, revealing distinct transcriptomes and metabolic states in different tissues and species.

bioRxiv · Dec 20, 2021 · PreprintImmunology

CD4+CCR6+ T cells dominate the BCG-induced transcriptional signature

A. Singhania, P. Dubelko, R. Kuan, W. D. Chronister, K. Muskat, J. Das, E. J. Phillips, S. A. Mallal, G. Seumois, P. Vijayanand, A. Sette, M. Lerm, B. Peters, C. S. Lindestam Arlehamn

This study identifies CD4+CCR6+ T cells as key drivers of the BCG-induced transcriptional response, showing similar immune signatures across individuals.

bioRxiv · Aug 20, 2021Immunology

Transcriptome and Chromatin Landscape of iNKT cells are Shaped by Subset Differentiation and Antigen Exposure

M. P. Murray, I. Engel, G. Seumois, S. H. de la Mata, S. L. Rosales, A. Sethi, A. L. R. Premlal, G.-Y. Seo, J. Greenbaum, P. Vijayanand, J. P. Scott-Browne, M. Kronenberg

This study examines how iNKT cell subsets change in gene programs and chromatin structure across tissues and after antigen exposure, revealing long-term adaptability.

bioRxiv · Oct 27, 2020Immunology

Single-cell transcriptomic analysis of SARS-CoV-2 reactive CD4+ T cells

B. J. Meckiff, C. Ramirez-Suastegui, V. Fajardo, S. J. Chee, A. Kusnadi, H. Simon, A. Grifoni, E. Pelosi, D. Weiskopf, A. Sette, F. Ay, G. Seumois, C. Ottensmeier, P. Vijayanand

This study analyzes single-cell transcriptomes of SARS-CoV-2 reactive CD4+ T cells in COVID-19 patients, finding differences in cell types and gene expression between severe and mild disease.

bioRxiv · Jun 12, 2020Immunology

The challenge of distinguishing cell-cell complexes from singlet cells in non-imaging flow cytometry and single-cell sorting

J. G. Burel, M. Pozmanoy, C. S. Lindestam Arlehamn, G. Seumois, P. Vijayanand, A. Sette, B. Peters

The paper identifies molecular signatures and methods to distinguish cell-cell complexes from singlet cells in flow cytometry data, highlighting their impact on data interpretation.

bioRxiv · Jan 30, 2020Immunology

CD4+ follicular helper-like T cells are key players in anti-tumor immunity

D. Singh, A. P. Ganesan, B. Panwar, S. Eschweiler, C. Hanley, A. Madrigal, C. Ramirez Suastegui, A. Wang, J. Clarke, O. Wood, E. M. Garrido-Martin, S. Chee, G. Seumois, S. Belanger, A. Alzetani, , P. Vijayanand

The paper identifies CD4+ follicular helper-like T cells as critical for enhancing anti-tumor CD8+ T cell responses and tumor growth inhibition.

bioRxiv · Jan 8, 2020 · PreprintImmunology

No cell is an island: circulating T cell:monocyte complexes are markers of immune perturbations

J. G. Burel, M. Pomaznoy, C. S. Lindestam Arlehamn, D. Weiskopf, R. da Silva Antunes, Y. Jung, V. Schulten, M. Babor, G. Seumois, J. A. Greenbaum, S. Premawansa, G. Premawansa, A. Wijewickrama, D. Vidanagama, B. Gunasena, , B. Peters

The paper identifies T cell:monocyte complexes in human blood as biological immune interactions, not technical artifacts, and shows their frequency changes with immune perturbations.

bioRxiv · Feb 21, 2019 · PreprintImmunology

Evidence that recurrent Group A streptococcus tonsillitis is animmunosusceptibility disease involving antibody deficiency and aberrant Tfh cells

J. M. Dan, C. Havenar-Daughton, K. Kendric, K. Kaushik, S. Rosales, E. Anderson, C. LaRock, P. Vijayanand, G. Seumois, D. Layfield, R. Cutress, C. Ottensmeier, C. Lindestam Arlehamn, A. Sette, V. Nizet, , S. Crotty

The paper investigates recurrent Group A Streptococcus tonsillitis and finds it involves antibody deficiency and aberrant Tfh cells, with genetic factors contributing to susceptibility.

bioRxiv · Jun 27, 2018Immunology