C. S. Lindestam Arlehamn

Identification of differentially recognized T cell epitopes in the spectrum of Mtb infection

The paper identifies differentially recognized T cell epitopes in Mtb infection stages using a proteome-wide screen and Fluorospot assay, revealing epitopes specific to active TB and potential vaccine targets.

High-parameter phenotypic characterization reveals a subset of human Th17 cells that preferentially produce IL17 against M. tuberculosis antigen.

The paper identifies two subsets of Th17 cells in HIV-ART-treated individuals with latent TB, showing subset 1 is reduced while IL17-producing cells remain, and links tryptophan catabolism to Th17 cell frequencies.

Profile of Mycobacterium tuberculosis-specific CD4 T cells at the site of disease and blood in pericardial tuberculosis

This study compares Mtb-specific CD4 T cell profiles in pericardial fluid and blood from PCTB patients, finding distinct phenotypes in PCF with no difference in cytokine production.

Peripheral blood T-cell deficiency and hyperinflammatory monocyte responses associate with MAC lung disease

The paper investigates immune responses in individuals with MAC lung disease, finding reduced T-cell responses and hyperinflammatory monocyte activity.

Transcriptional analysis of peripheral memory T cells reveals Parkinson's disease-specific gene signatures

The paper identifies PD-specific gene signatures in peripheral memory T cells by analyzing RNA-seq data from PD patients and healthy controls.

CD4 T cells are rapidly depleted from tuberculosis granulomas following acute SIV co-infection

This study shows that acute SIV co-infection rapidly depletes CD4 T cells from tuberculosis granulomas before systemic CD4 T cell loss or disease reactivation.

CD4+CCR6+ T cells dominate the BCG-induced transcriptional signature

This study identifies CD4+CCR6+ T cells as key drivers of the BCG-induced transcriptional response, showing similar immune signatures across individuals.

A novel Mycobacterium tuberculosis-specific subunit vaccine provides synergistic immunity upon co-administration with Bacillus Calmette-Guerin

This study develops a Mycobacterium tuberculosis-specific subunit vaccine, H107, which when co-administered with BCG enhances immune responses and provides better protection than either vaccine alone.

Functional inactivation of pulmonary MAIT cells following 5-OP-RU treatment of non-human primates

This study shows that 5-OP-RU treatment of M. tuberculosis-infected rhesus macaques leads to MAIT cell dysfunction rather than expansion, with upregulated PD-1 and loss of cytokine production.

The challenge of distinguishing cell-cell complexes from singlet cells in non-imaging flow cytometry and single-cell sorting

The paper identifies molecular signatures and methods to distinguish cell-cell complexes from singlet cells in flow cytometry data, highlighting their impact on data interpretation.

No cell is an island: circulating T cell:monocyte complexes are markers of immune perturbations

The paper identifies T cell:monocyte complexes in human blood as biological immune interactions, not technical artifacts, and shows their frequency changes with immune perturbations.