Author

G. T. Nguyen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:bacteria (other)· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

D. G. Sashital· 2 shared M. A. Schelling· 2 shared A. Garcia-Sastre· 1 shared A. Sritharan· 1 shared A.-K. Reuschl· 1 shared C. Jolly· 1 shared D. B. Sykes· 1 shared D. Swaney· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersBiochemistry

D. G. Sashital

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

BiochemistrybioRxivNov 29, 2023

CRISPR-Cas12a exhibits metal-dependent specificity switching

G. T. Nguyen, M. A. Schelling, K. A. Buscher…·D. G. Sashital

This study shows that Cas12a's specificity changes with Mg2+ concentration, affecting cleavage efficiency and phage escape routes in different cellular environments.

DOI 10.1093/nar/gkae613

experimental assayhost-pathogen & immune response

MicrobiologybioRxivPreprintMay 30, 2022

CRISPR-Cas effector specificity and target mismatches determine phage escape outcomes

M. A. Schelling, G. T. Nguyen, D. G. Sashital

This study shows that Cas12a mismatch tolerance and pre-existing target mismatches influence phage evolution, with liquid media leading to more phage escape despite in vitro cleavage activity.

DOI 10.1101/2022.05.30.494023

bacteria (other)DNA methylation

ImmunologybioRxivMar 2, 2021

Neutrophils require SKAP2 for reactive oxygen species production following C-type lectin and Candida stimulation

G. T. Nguyen, S. Xu, S. C. Bunnell…·J. Mecsas

This study shows SKAP2 is essential for neutrophil ROS production in response to C-type lectin receptors and Candida infections, expanding its role beyond antibacterial immunity.

DOI 10.1016/j.isci.2021.102871

mouseproteomics

MicrobiologybioRxivPreprintJan 24, 2021

Host-directed therapies against early-lineage SARS-CoV-2 retain efficacy against B.1.1.7 variant

A.-K. Reuschl, L. Thorne, L. Zuliani Alvarez…·N. J. Krogan

This study evaluates the efficacy of host-directed therapies against the B.1.1.7 SARS-CoV-2 variant and finds similar antiviral activity compared to early-lineage SARS-CoV-2.

DOI 10.1101/2021.01.24.427991

humanexperimental assay