NEO-AAV: an engineered extracellular vesicle-enveloped AAV platform for activation-coupled T cell transduction and CAR-T cell generation
Songpu Xie, Qiangbing Yang, Lisa V. Jansen, Bing Yao, Geng Yang, Kaiyong Qu, Pieter Vader, C. Snijders Blok, Saskia C.A. de Jager, Gerard J.J. Boink, Raymond Michel Schiffelers, Pieter A. Doevendans, J N Xiao, Joost P. G. Sluijter, Zhiyong Lei
This paper introduces NEO-AAV, an engineered AAV platform that enhances T cell transduction and CAR-T cell generation by enveloping AAV in extracellular vesicles, improving immune resistance and transduction efficiency.
bioRxiv · May 30, 2026 · PreprintBioengineering