Human airway organoids as a high-throughput screening platform for antiviral natural products discovery
Mathieu Hubert, Paola Haemmerli, Laurence Marcourt, Emy Lara-Quintero, Loan Arthaud, Luis-Manuel Quirós-Guerrero, Sarah Donnaray, Katia Rimensberger, Arnaud Gaudry, Élodie Alessandri-Gradt, Georgios Stroulios, Yves Cambet, François Prodon, Bohumil Maco, Samuel Constant, , Caroline Tapparel
This study uses human airway organoids to screen 764 natural plant extracts for antiviral activity against RSV, identifying 45 active compounds with distinct mechanisms.
bioRxiv · Feb 4, 2026 · PreprintMicrobiology