Author

N. K. Das

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 3 Approach:statistical model· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

Y. M. Shah· 5 shared C. A. Lyssiotis· 3 shared J. D. Mancias· 3 shared S. Solanki· 3 shared C. Castillo· 2 shared H. Bell· 2 shared M. O. El-Derany· 2 shared R. Singhal· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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5 shared papersCancer Biology

Y. M. Shah

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Author profile →

5 papers

Recent·Most cited

Recharacterization of RSL3 reveals that the selenoproteome is a druggable target in colorectal cancer

S. L. DeAngelo, L. Zhao, S. Dziechciarz, M. Shin, S. Solanki, A. Balia, M. O. El-Derany, C. Castillo, Y. Qin, N. K. Das, H. N. Bell, J. A. Paulo, Y. Zhang, N. J. Rossiter, E. C. McCulla, , Y. M. Shah

This study recharacterizes RSL3 as a broad selenoprotein inhibitor, showing its potential as a therapeutic target for colorectal cancer by inducing ferroptosis.

bioRxiv · Mar 29, 2024 · PreprintCancer Biology

PINK1 supports colorectal cancer growth by regulating the labile iron pool.

B. Chen, N. K. Das, I. Talukdar, R. Singhal, C. Castillo, A. Andren, J. D. Mancias, C. A. Lyssiotis, Y. M. Shah

This study shows PINK1 supports colorectal cancer growth by regulating the labile iron pool through mitophagy and ferritinophagy.

bioRxiv · Sep 27, 2022 · PreprintCancer Biology

Microenvironmental Ammonia Enhances T cell Exhaustion in Colorectal Cancer

Y. M. Shah, H. Bell, A. K. Huber, R. Singhal, R. J. Rebernick, R. Kumar, N. K. Das, S. A. Kerk, P. Sajjakulnukit, S. Solanki, J. G. James, D. Kim, L. Zhang, M. O. El-derany, T. L. Frankel, , M. Green

This study shows that ammonia accumulation in the colorectal cancer microenvironment promotes T cell exhaustion and treatment resistance, and that reducing ammonia improves immunotherapy efficacy.

bioRxiv · May 25, 2022Cancer Biology

Microbiota metabolic exchange is critical for colorectal cancer redox homeostasis and growth

H. Bell, J. Goyert, S. A. Kerk, N. K. Das, C. A. Lyssiotis, Y. M. Shah

This study identifies reuterin as a microbial metabolite that suppresses colorectal cancer growth by altering redox balance and inducing cell death.

bioRxiv · Dec 2, 2020 · PreprintCancer Biology

Intestinal ferritinophagy is regulated by HIF-2 and is essential for systemic iron homeostasis

N. K. Das, A. Sankar, A. J. Schwartz, S. Solanki, X. Ma, S. Parimi, N. Santana-Codina, J. D. Mancias, Y. M. Shah

This study shows HIF-2 regulates intestinal ferritinophagy via NCOA4, which is essential for systemic iron homeostasis.

bioRxiv · Nov 1, 2020 · PreprintPhysiology